منابع مشابه
Glycosaminoglycan Metabolism in p-Aminopropionitrile-Treated Chick Embryos
1. Na235SO4, (1-14C]glucosamine and [1-14C]acetate were used as precursors of the sulphated glycosaminoglycans to study the biochemical effect of P-aminopropionitrile in chick embryos. The incorporation of all three precursors was decreased in the treated embryos between days 7 and 10 of embryonic development. No inhibition of incorporation of these precursors occurred between days 16 and 20 of...
متن کاملMetabolism of a Glycosaminoglycan during Metamorphosis in the Japanese Conger eel, Conger myriaster
Hyaluronan (HA) is a linear polysaccharide of high molecular weight that exists as a component of the extracellular matrix. The larvae (leptocephali) of the Japanese conger eel (Anguilliformes: Conger myriaster) have high levels of hyaluronan (HA) which is thought to help control body water content. We isolated glycosaminoglycans (GAGs) from Japanese conger eel leptocephali and measured the cha...
متن کاملModulation of expression of genes involved in glycosaminoglycan metabolism and lysosome biogenesis by flavonoids
Flavonoids were found previously to modulate efficiency of synthesis of glycosaminoglycans (GAGs), compounds which are accumulated in cells of patients suffering from mucopolysaccharidoses (MPSs). The aim of this work was to determine effects of different flavonoids (genistein, kaempferol, daidzein) used alone or in combinations, on expression of genes coding for proteins involved in GAG metabo...
متن کاملGlycosaminoglycan and collagen metabolism in arylsulfatase B-deficient retinal pigment epithelium in vitro.
Regional differences in retinal pigment epithelial (RPE) cell glycosaminoglycan (GAG) and collagen metabolism were studied using cells obtained from normal cats and those with deficient activity of arylsulfatase B (ASB), a lysosomal enzyme involved in GAG catabolism. Control and ASB-deficient RPE cultures initiated from superior equatorial (superior) and inferior equatorial (inferior) regions o...
متن کاملAltered metabolism of thrombospondin by Chinese hamster ovary cells defective in glycosaminoglycan synthesis.
We examined the ability of Chinese hamster ovary (CHO) cell mutants defective in glycosaminoglycan synthesis to metabolize 125I-labeled thrombospondin (TSP). Wild type CHO cells bound and degraded 125I-TSP with kinetics similar to those reported for endothelial cells. Both binding and degradation were saturable (half-saturation at 20 micrograms/ml). When the concentration of labeled TSP was 1-5...
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ژورنال
عنوان ژورنال: Reactome - a curated knowledgebase of biological pathways
سال: 2012
ISSN: 1934-1792
DOI: 10.3180/react_121315.1